Primary adult intratesticular rhabdomyosarcoma: results of the treatment of six cases

Int J Urol. 2011 Feb;18(2):171-4. doi: 10.1111/j.1442-2042.2010.02685.x. Epub 2010 Dec 22.

Abstract

The aim of the present study was to assess the treatment outcomes in a cohort of adult patients with intratesticular rhabdomyosarcoma. Between 1999 and 2008, 296 patients underwent radical orchiectomy for intrascrotal mass. A retrospective chart review was carried out for adult patients diagnosed with intratesticular rhabdomyosarcoma. Overall, six patients (mean age 21 years, range 17-23) were included: five had embryonic rhabdomyosarcoma and one had pleomorphic rhabdomyosarcoma. Four patients underwent retroperitoneal lymph node dissection and five patients had postoperative chemotherapy. The mean length of follow up was 28 months (range 12-51 months). One patient was lost to follow up after 26 months, five cases remained alive at the end of the study. Surgical resection with chemotherapy was an effective way to achieve favorable outcomes and long-term survival in adult patients with metastases from intratesticular rhabdomyosarcoma.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Antineoplastic Combined Chemotherapy Protocols
  • Chemotherapy, Adjuvant
  • Cyclophosphamide
  • Dactinomycin
  • Humans
  • Male
  • Orchiectomy
  • Retrospective Studies
  • Rhabdomyosarcoma / drug therapy
  • Rhabdomyosarcoma / surgery*
  • Testicular Neoplasms / drug therapy
  • Testicular Neoplasms / surgery*
  • Vincristine
  • Young Adult

Substances

  • Dactinomycin
  • Vincristine
  • Cyclophosphamide

Supplementary concepts

  • VAC protocol