Abstract
PCNA (proliferating-cell nuclear antigen) is a ring-shaped protein that encircles duplex DNA and plays an essential role in many DNA metabolic processes. The PCNA protein interacts with a large number of cellular factors and modulates their enzymatic activities. In the present paper, we summarize the structures, functions and interactions of the archaeal PCNA proteins.
Publication types
-
Research Support, U.S. Gov't, Non-P.H.S.
-
Review
MeSH terms
-
Archaeal Proteins / chemistry*
-
Archaeal Proteins / genetics
-
Archaeal Proteins / metabolism*
-
DNA / genetics
-
DNA / metabolism
-
DNA Replication
-
Humans
-
Models, Molecular
-
Proliferating Cell Nuclear Antigen / chemistry*
-
Proliferating Cell Nuclear Antigen / genetics
-
Proliferating Cell Nuclear Antigen / metabolism*
-
Protein Conformation
Substances
-
Archaeal Proteins
-
Proliferating Cell Nuclear Antigen
-
DNA