The archaeal PCNA proteins

Biochem Soc Trans. 2011 Jan;39(1):20-4. doi: 10.1042/BST0390020.

Abstract

PCNA (proliferating-cell nuclear antigen) is a ring-shaped protein that encircles duplex DNA and plays an essential role in many DNA metabolic processes. The PCNA protein interacts with a large number of cellular factors and modulates their enzymatic activities. In the present paper, we summarize the structures, functions and interactions of the archaeal PCNA proteins.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Archaeal Proteins / chemistry*
  • Archaeal Proteins / genetics
  • Archaeal Proteins / metabolism*
  • DNA / genetics
  • DNA / metabolism
  • DNA Replication
  • Humans
  • Models, Molecular
  • Proliferating Cell Nuclear Antigen / chemistry*
  • Proliferating Cell Nuclear Antigen / genetics
  • Proliferating Cell Nuclear Antigen / metabolism*
  • Protein Conformation

Substances

  • Archaeal Proteins
  • Proliferating Cell Nuclear Antigen
  • DNA