Putting the brakes on the anti-viral response: negative regulators of type I interferon (IFN) production

Kathryn H Richards; Andrew Macdonald

doi:10.1016/j.micinf.2010.12.007

Putting the brakes on the anti-viral response: negative regulators of type I interferon (IFN) production

Microbes Infect. 2011 Apr;13(4):291-302. doi: 10.1016/j.micinf.2010.12.007. Epub 2011 Jan 20.

Authors

Kathryn H Richards¹, Andrew Macdonald

Affiliation

¹ Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK.

PMID: 21256242
DOI: 10.1016/j.micinf.2010.12.007

Abstract

Type I IFNs (IFNα/β) are essential anti-viral cytokines produced in response to the detection of viral components by host pattern recognition receptors. IFNα/β production is transient, and aberrant activation can be hazardous to the host. In this article, we review our current understanding of host negative regulatory mechanisms that control IFNα/β production.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cytoplasm / metabolism
Host-Pathogen Interactions / immunology*
Humans
Immunity, Innate / immunology*
Immunomodulation*
Interferon Regulatory Factors / metabolism
Interferon Type I / biosynthesis*
Interferon Type I / immunology*
Protein Serine-Threonine Kinases / metabolism
RNA, Viral / metabolism
Signal Transduction
Toll-Like Receptors / immunology
Virus Diseases / immunology*
Viruses / immunology

Substances

Interferon Regulatory Factors
Interferon Type I
RNA, Viral
Toll-Like Receptors
Protein Serine-Threonine Kinases