Laevigatbenzoate from Croton laevigatus Vahl

Guo-An Zou; Hong-Wu Zhang; Haji Akber Aisa; Jun-Shan Yang; Chao-Zhong Peng; Zhong-Mei Zou

doi:10.1007/s11418-010-0503-9

Laevigatbenzoate from Croton laevigatus Vahl

J Nat Med. 2011 Apr;65(2):391-4. doi: 10.1007/s11418-010-0503-9. Epub 2011 Jan 21.

Authors

Guo-An Zou¹, Hong-Wu Zhang, Haji Akber Aisa, Jun-Shan Yang, Chao-Zhong Peng, Zhong-Mei Zou

Affiliation

¹ Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, People's Republic of China.

PMID: 21253863
DOI: 10.1007/s11418-010-0503-9

Abstract

A new trans-clerodane diterpenoid, laevigatbenzoate (1), was isolated from the leaves of Croton laevigatus Vahl. Its structure was established on the basis of spectroscopic analysis, and the absolute configuration was determined by application of the CD excitation chirality method. This compound showed weak cytotoxicity against HeLa cells, with an IC(50) value of 45.4 μM.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / chemistry*
Antineoplastic Agents, Phytogenic / pharmacology*
Cell Survival / drug effects
Croton
Diterpenes / chemistry*
Diterpenes / pharmacology*
HeLa Cells
Humans
Magnetic Resonance Spectroscopy
Molecular Structure
Plant Leaves / chemistry

Substances

Antineoplastic Agents, Phytogenic
Diterpenes