Abstract
This work develops an electrochemical approach for rapid detection of the genomic DNA methylation level, assay of methyltransferase activity, and evaluation and screening of the inhibitors of methyltransferase. This method may be a help for the discovery of anticancer drugs.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Base Sequence
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CpG Islands
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DNA / chemistry
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DNA / genetics*
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DNA / metabolism
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DNA Methylation*
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Electrochemistry / methods*
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Enzyme Assays / methods*
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Methyltransferases / metabolism*
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Models, Molecular
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Nucleic Acid Conformation
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Time Factors