Total synthesis of (-)-brevisin: a concise synthesis of a new marine polycyclic ether

Org Lett. 2011 Feb 18;13(4):696-9. doi: 10.1021/ol102925d. Epub 2011 Jan 19.

Abstract

The first and highly efficient total synthesis of (-)-brevisin has been achieved. The title compound was synthesized in only 29 steps (longest linear sequence) from commercially available starting materials. The synthesis provided over 70 mg of a marine polycyclic ether compound.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Dinoflagellida / chemistry
  • Ethers, Cyclic / chemical synthesis*
  • Ethers, Cyclic / chemistry
  • Marine Biology
  • Molecular Structure
  • Polycyclic Compounds / chemical synthesis*
  • Polycyclic Compounds / chemistry
  • Stereoisomerism

Substances

  • Ethers, Cyclic
  • Polycyclic Compounds
  • brevisin