Abstract
An efficient rhodium/diene-catalyzed asymmetric addition of arylboronic acids to α,β-unsaturated γ-lactams has been developed. The power of this methodology is further demonstrated by the concise synthesis of (R)-baclofen and (R)-rolipram.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Baclofen / chemical synthesis*
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Baclofen / chemistry
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Boronic Acids / chemistry*
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Catalysis
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Molecular Structure
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Rhodium / chemistry*
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Rolipram / chemical synthesis*
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Rolipram / chemistry
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Stereoisomerism
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beta-Lactams / chemical synthesis*
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beta-Lactams / chemistry
Substances
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Boronic Acids
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beta-Lactams
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Rhodium
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Baclofen
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Rolipram