Modulation of reparative regeneration and CD117 expression by liver cells after partial hepatectomy in mice

B G Yushkov; I G Danilova; Zh B Ponezheva; I A Brykina; M T Abidov; O V Kalyuzhin

doi:10.1007/s10517-011-1140-3

Modulation of reparative regeneration and CD117 expression by liver cells after partial hepatectomy in mice

Bull Exp Biol Med. 2011 Jan;150(3):352-4. doi: 10.1007/s10517-011-1140-3.

Authors

B G Yushkov¹, I G Danilova, Zh B Ponezheva, I A Brykina, M T Abidov, O V Kalyuzhin

Affiliation

¹ Institute of Immunology and Physiology, Ural Division of the Russian Academy of Sciences, Ekaterinburg, Russia.

PMID: 21240352
DOI: 10.1007/s10517-011-1140-3

Abstract

The effects of 3-aminophthalhydrazide and carrageenan on reparative regeneration and expression of CD117 by liver cells after partial hepatectomy were studied in mice. 3-Aminophthalhydrazide stimulated regeneration of the liver and increased the count of CD117(+) hepatocytes. By contrast, carrageenan inhibited liver reparation and CD117 expression.

MeSH terms

Animals
Carrageenan / pharmacology
Cell Count
Hepatectomy*
Immunohistochemistry
Ki-67 Antigen / metabolism
Liver / metabolism*
Liver Regeneration / drug effects
Liver Regeneration / physiology*
Luminescent Agents / pharmacology
Luminol / analogs & derivatives
Luminol / pharmacology
Mice
Proto-Oncogene Proteins c-kit / metabolism*
Statistics, Nonparametric

Substances

Ki-67 Antigen
Luminescent Agents
isoluminol
Luminol
Carrageenan
Proto-Oncogene Proteins c-kit