Abstract
The total synthesis of the 43 amino acid antibacterial peptide Microcin B17 (MccB17) is described. The natural product was synthesized via a convergent approach from a heterocycle-derived peptide and peptide thioester fragments prepared via Fmoc-strategy solid phase peptide synthesis (SPPS). Final assembly was achieved in an efficient manner using two Ag(I)-assisted peptide ligation reactions to afford MccB17 in excellent overall yield.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Amino Acids / chemistry*
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology
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Bacteriocins / chemical synthesis*
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Bacteriocins / chemistry
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Bacteriocins / pharmacology
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Escherichia coli Proteins / chemical synthesis*
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Escherichia coli Proteins / chemistry
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Escherichia coli Proteins / pharmacology
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Molecular Structure
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Peptides / chemical synthesis*
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Peptides / chemistry
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Peptides / pharmacology
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Silver / chemistry
Substances
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Amino Acids
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Anti-Bacterial Agents
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Bacteriocins
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Escherichia coli Proteins
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Peptides
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microcin
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Silver