P2Y12 receptor in platelet activation

Platelets. 2011;22(1):56-60. doi: 10.3109/09537104.2010.497231.

Abstract

ADP plays an important role in hemostasis and thrombosis. The P2Y12 receptor, activated by ADP, plays a central role in platelet activation and thrombus formation. Thus, the P2Y12 receptor has been an effective target for antithrombotic drugs.

Publication types

  • Review

MeSH terms

  • Adenosine Diphosphate / metabolism*
  • Animals
  • Blood Coagulation / drug effects
  • Blood Platelets / drug effects
  • Blood Platelets / physiology
  • Fibrinolytic Agents / pharmacology
  • Fibrinolytic Agents / therapeutic use
  • Humans
  • Membrane Proteins / metabolism*
  • Mice
  • Platelet Activation / drug effects
  • Platelet Activation / physiology
  • Platelet Aggregation / drug effects
  • Platelet Aggregation / physiology
  • Purinergic Agents / pharmacology*
  • Purinergic Agents / therapeutic use
  • Receptors, Purinergic P2 / metabolism*
  • Signal Transduction
  • Thrombosis / drug therapy

Substances

  • Fibrinolytic Agents
  • Membrane Proteins
  • Purinergic Agents
  • Receptors, Purinergic P2
  • Adenosine Diphosphate