Abstract
ADP plays an important role in hemostasis and thrombosis. The P2Y12 receptor, activated by ADP, plays a central role in platelet activation and thrombus formation. Thus, the P2Y12 receptor has been an effective target for antithrombotic drugs.
MeSH terms
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Adenosine Diphosphate / metabolism*
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Animals
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Blood Coagulation / drug effects
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Blood Platelets / drug effects
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Blood Platelets / physiology
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Fibrinolytic Agents / pharmacology
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Fibrinolytic Agents / therapeutic use
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Humans
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Membrane Proteins / metabolism*
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Mice
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Platelet Activation / drug effects
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Platelet Activation / physiology
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Platelet Aggregation / drug effects
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Platelet Aggregation / physiology
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Purinergic Agents / pharmacology*
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Purinergic Agents / therapeutic use
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Receptors, Purinergic P2 / metabolism*
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Signal Transduction
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Thrombosis / drug therapy
Substances
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Fibrinolytic Agents
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Membrane Proteins
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Purinergic Agents
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Receptors, Purinergic P2
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Adenosine Diphosphate