Virus infection speeds: theory versus experiment

Phys Rev E Stat Nonlin Soft Matter Phys. 2010 Dec;82(6 Pt 1):061905. doi: 10.1103/PhysRevE.82.061905. Epub 2010 Dec 14.

Abstract

In order to explain the speed of Vesicular Stomatitis Virus (VSV) infections, we develop a simple model that improves previous approaches to the propagation of virus infections. For VSV infections, we find that the delay time elapsed between the adsorption of a viral particle into a cell and the release of its progeny has a very important effect. Moreover, this delay time makes the adsorption rate essentially irrelevant in order to predict VSV infection speeds. Numerical simulations are in agreement with the analytical results. Our model satisfactorily explains the experimentally measured speeds of VSV infections.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line
  • Cricetinae
  • Diffusion
  • Models, Biological*
  • Reproducibility of Results
  • Time Factors
  • Vesicular Stomatitis*
  • Vesiculovirus / physiology*