Implication of oncogenic signaling pathways as a treatment strategy for neurodegenerative disorders - contemporary approaches

CNS Neurol Disord Drug Targets. 2011 Mar;10(2):175-83. doi: 10.2174/187152711794480410.

Abstract

Recent evidence has associated the aberrant, proximal re-expression of various cell cycle control elements with neuronal cell vulnerability in Alzheimer's and Parkinson's diseases, as a common chronic neurodegeneration. This phenomenon associated with oncogenic transduction pathway activation has attracted the interest of scientists all over the world for a few years now. The purpose of this paper is to outline areas of research related to oncogenic factors or medicines in the context of potential applications for future treatment of the above mentioned chronic and, largely, incurable diseases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alzheimer Disease / drug therapy
  • Alzheimer Disease / metabolism*
  • Cell Cycle
  • Humans
  • Nerve Degeneration / metabolism
  • Neurodegenerative Diseases / drug therapy*
  • Neurodegenerative Diseases / metabolism*
  • Neurons / metabolism
  • Neurons / pathology
  • Nuclear Pore Complex Proteins / metabolism
  • Oncogene Proteins / metabolism*
  • Oncogenes*
  • Oxidative Stress
  • Parkinson Disease / metabolism
  • Parkinson Disease / pathology
  • Signal Transduction*

Substances

  • Nuclear Pore Complex Proteins
  • Oncogene Proteins