The present study was carried out on 429 children below 6 years of age from a village in Bani-Suef governorate to show the schistosomiasis prevalence rate among them. Direct sedimentation techniques of the urine and stool beside an indirect serological test (Dot-ELISA) were used for the diagnosis. The results indicate 14.5% and 26.3% positive cases as detected parasitologically and serologically, respectively. Other parasitic infections were also diagnosed. The serologic test enabled us to differentiate acute from chronic schistosomiasis cases in the studied sample. The serologically positive infants may suggested the congenital transmission of immunologic information rather than active infection. On the other hand, there were no correlations between the schistosomiasis incidence and both the anthropometric measurement and organ involvements.