Influence of estroprogestinic therapy on the postoperative course following impacted third molar extraction

Minerva Stomatol. 2010 Nov-Dec;59(11-12):611-23.
[Article in English, Italian]

Abstract

Aim: Female patients on estroprogestinic therapy undergoing extraction of the third lower molar have a higher incidence of postoperative complications (dry socket -DS- pain). The purpose of this study is to verify such data and analyse if there are risk factors for the appearance of other postoperative complications.

Methods: One hundred eighteen non-smoking healthy patients were included who underwent extraction of the impacted third lower molar (38 on oral contraceptives, OC, 80 as control). After the extraction, patients were prescribed with a pharmacological therapy, consisting of a per os antibiotic and antiseptic rinse. Each patient was examined after 7 days following surgery to verify the state of tissues. In addition subjective postoperative pain (VAS - Visual Analogue Scale) and intake of analgesic drugs were recorded.

Results: One case of DS (2.64%) occurred in the OC group, and 1 case of DS occurred in control-patients group (1.25%) (P=0.4436). The postoperative pain proved significantly higher in OC compared to control (first and fifth postoperation day). In OC a predisposition to dehiscence of the wound (86.84% P=0.0021) and emergence of laterocervical lymphadenitis (81.57% P=0.0010) was found, while no cases of postextractive abscesses and trismus of the masseter were found.

Conclusion: Although no correlation between DS and estroprogestinic therapy has been found, a more difficult healing of tissues has been observed as well as a significantly higher subjective pain index in the postoperative days considered in OC patients.

MeSH terms

  • Adolescent
  • Adult
  • Contraceptives, Oral, Combined / adverse effects*
  • Drug Combinations
  • Dry Socket / chemically induced*
  • Dry Socket / epidemiology
  • Ethinyl Estradiol / adverse effects*
  • Female
  • Humans
  • Middle Aged
  • Molar*
  • Norpregnenes / adverse effects*
  • Postoperative Complications / chemically induced*
  • Postoperative Complications / epidemiology
  • Risk Factors
  • Tooth Extraction*
  • Tooth, Impacted / surgery*
  • Young Adult

Substances

  • Contraceptives, Oral, Combined
  • Drug Combinations
  • Norpregnenes
  • estroprogestin
  • Ethinyl Estradiol