Collagen can link between or within collagen molecules through the covalent bond, which leads to increasing the tension and stability of collagen fiber. Collagen cross-linking had been widely used in other industries, the recent research showed that cross-linking of scleral collagen increased the scleral biomechanical rigidity efficiently, which might become a new treatment modality for strengthening scleral tissue to prevent progressive myopia. This review describes the sclera collagen characteristics of progressive myopia, traditional treatment and sclera collagen cross-linking therapy.