Recognition tunneling measurement of the conductance of DNA bases embedded in self-assembled monolayers

J Phys Chem C Nanomater Interfaces. 2010 Dec 9;114(48):20443-20448. doi: 10.1021/jp104792s.

Abstract

The DNA bases interact strongly with gold electrodes, complicating efforts to measure the tunneling conductance through hydrogen-bonded Watson Crick base pairs. When bases are embedded in a self-assembled alkane-thiol monolayer to minimize these interactions, new features appear in the tunneling data. These new features track the predictions of density-functional calculations quite well, suggesting that they reflect tunnel conductance through hydrogen-bonded base pairs.