Abstract
Ca(+)-dependent Cl⁻ channels (CaCCs) play a variety of physiological roles in different organs and tissues, including transepithelial Cl⁻ secretion, smooth muscle contraction, regulation of neuronal excitability, and transduction of sensory stimuli. The recent identification of TMEM16A protein as an important component of CaCCs should allow a better understanding of their physiological role, structure-function relationship, and regulatory mechanisms.
MeSH terms
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Animals
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Anoctamin-1
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Chloride Channels / chemistry
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Chloride Channels / metabolism*
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Chlorides / metabolism*
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Epithelial Cells / metabolism
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Humans
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Kinetics
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Membrane Proteins / chemistry
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Membrane Proteins / metabolism*
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Myocytes, Smooth Muscle / metabolism
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Neoplasm Proteins / chemistry
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Neoplasm Proteins / metabolism*
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Neoplasms / metabolism
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Neurons / metabolism
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Protein Conformation
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Signal Transduction
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Structure-Activity Relationship
Substances
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ANO1 protein, human
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ANO1 protein, mouse
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ANO1 protein, rat
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Anoctamin-1
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Chloride Channels
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Chlorides
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Membrane Proteins
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Neoplasm Proteins