Ammonium ylides for the diastereoselective synthesis of glycidic amides

Chem Commun (Camb). 2011 Feb 21;47(7):2170-2. doi: 10.1039/c0cc04821f. Epub 2010 Dec 21.

Abstract

A highly trans-selective protocol for the synthesis of glycidic amides was developed. This approach gave access to oxiranes by reacting stabilised ammonium ylides bearing an α-carbonyl group and aromatic aldehydes in moderate to good yields.