End-stapled homo and hetero collagen triple helices: a click chemistry approach

Chem Commun (Camb). 2011 Mar 7;47(9):2589-91. doi: 10.1039/c0cc04795c. Epub 2010 Dec 21.

Abstract

A CuAAC reaction was established for modular synthesis of end-stapled homo- and hetero-triple helical peptides, generating "clicked" macro-assemblies with enhanced thermal stability.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkynes / chemistry
  • Amino Acid Sequence
  • Azides / chemistry
  • Calorimetry, Differential Scanning
  • Catalysis
  • Circular Dichroism
  • Click Chemistry
  • Collagen / chemical synthesis
  • Collagen / chemistry*
  • Copper / chemistry

Substances

  • Alkynes
  • Azides
  • Copper
  • Collagen