The European Society for Medical Oncology (ESMO) Congress is organized by the ESMO every second year, alternating with the European Cancer Organisation-ESMO-European Society for Therapeutic Radiology and Oncology multidisciplinary cancer conference. The ESMO Congress provides current information on the latest research results in medical oncology and offers state-of-the-art educational programs to support medical oncologists in their training and practice. A record number of attendees (16,000 people) made the 35th ESMO Congress a great success, including over 13,000 oncologists and other cancer healthcare professionals, 360 media representatives and 400 cancer patients who participated in a dedicated seminar. To contextualize the magnitude of the data reported, it should be noted that over 63,000 patients have been treated in the randomized studies that were presented.