Objective: To investigate whether hyperIgEaemia is associated with Hirayama disease in China.
Methods: Serum total IgE were examined in 123 patients and 82 control subjects from 2006 to 2009 at this hospital and their correlations with clinical profiles investigated. The data were analyzed by t, Chi-square and nonparametric tests.
Results: Past or present history of allergy/atopy was found in 14 (11.4%) patients and 11(13.4%)controls. The median value of serum total IgE were 87.97, 59.21 and 51.39 IU/ml in patients, controls and health controls respectively. There were no significant difference between the patient and control groups (Z = -0.947, P = 0.344) and the health control groups (Z = -0.914, P = 0.361). Serum IgE was elevated in 57 (43.6%) patients and 30 (36.6%) controls. HyperIgEaemia was present in 29 (23.6%) patients and 13 (15.9%) controls. There was no significant difference in the frequency of history of allergy/atopy, IgE elevation or hyperIgEaemia (P > 0.05) between cases and controls. Even after analyzing the length of duration or the severity of clinical disabilities, there was no difference neither (P > 0.05).
Conclusion: Whether the length of duration or the severity of clinical disabilities, the serum total IgE level has no significant difference between all groups. HyperIgEaemia is not associated with Hirayama disease.