Abstract
The vitamin E analogues (2R,4'R,8'R)-nor-α-tocopherol (94 % de) and (2RS,4'R,8'R)-nor-α-tocopherol have been synthesized from (all R)-hexahydrofarnesol and phytol, respectively. According to in vitro experiments with murine macrophages nor-α-tocopherol is an anti-inflammatory compound more potent than α-tocopherol.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antioxidants / chemical synthesis*
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Antioxidants / chemistry
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Antioxidants / pharmacology*
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Cell Line
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Cytokines / metabolism
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Inflammation / genetics
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Macrophages / drug effects
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Macrophages / enzymology
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Macrophages / metabolism
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Mice
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Models, Molecular
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Molecular Conformation
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Nitric Oxide Synthase Type II / metabolism
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RNA, Messenger / genetics
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RNA, Messenger / metabolism
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Stereoisomerism
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alpha-Tocopherol / analogs & derivatives
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alpha-Tocopherol / chemical synthesis*
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alpha-Tocopherol / chemistry
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alpha-Tocopherol / pharmacology*
Substances
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Antioxidants
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Cytokines
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RNA, Messenger
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Nitric Oxide Synthase Type II
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alpha-Tocopherol