Effect of NO inhibitors on hypovolemic shock-induced hypotension

S Ya Proskurjakov; M V Filimonova; O N Borovaya; N G Kucherenko; A I Trishkina; L V Shteyn; V G Skvortsov; L P Ul'yanova; L I Shevchenko; Yu G Verkhovsky

doi:10.1007/s10517-010-1057-2

Effect of NO inhibitors on hypovolemic shock-induced hypotension

Bull Exp Biol Med. 2010 Dec;150(1):18-22. doi: 10.1007/s10517-010-1057-2.

Authors

S Ya Proskurjakov¹, M V Filimonova, O N Borovaya, N G Kucherenko, A I Trishkina, L V Shteyn, V G Skvortsov, L P Ul'yanova, L I Shevchenko, Yu G Verkhovsky

Affiliation

¹ Medical Radiology Research Center, Russian Academy of Medical Sciences, Obninsk, Russia. pros@mrrc.obninsk.ru

PMID: 21161041
DOI: 10.1007/s10517-010-1057-2

Abstract

In vivo effect of isothiourea derivatives on NO production was studied by the method of electron paramagnetic resonance spectroscopy with a spin trap. We evaluated the influence of these compounds on hemodynamic parameters in anesthetized rats with hypovolemic shock. A correlation was found between the size of S,N-substituents in isothiourea derivatives (methyl, ethyl, and isopropyl) and NO inhibitory activity of compounds. The antihypotensive effect was more pronounced in compounds with high NO inhibitory activity containing the isopropyl radical.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antihypertensive Agents / chemistry
Antihypertensive Agents / therapeutic use*
Electron Spin Resonance Spectroscopy
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / therapeutic use*
Hemodynamics / drug effects
Hypotension / drug therapy*
Hypotension / etiology*
Male
Nitric Oxide Synthase / antagonists & inhibitors
Rats
Rats, Wistar
Shock / complications*
Thiourea / chemistry
Thiourea / therapeutic use*

Substances

Antihypertensive Agents
Enzyme Inhibitors
Nitric Oxide Synthase
Thiourea