2-[4-(4-Methoxyphenylcarbonyloxy)benzylidene]-6-dimethylaminomethyl cyclohexanone hydrochloride: a Mannich base which inhibits the growth of some drug-resistant strains of Mycobacterium tuberculosis

Pharmazie. 2010 Nov;65(11):849-50.

Abstract

2-[4-(4-Methoxyphenylcarbonyloxy)benzylidene]-6-dime-thylaminomethyl cyclohexanone hydrochloride 1 has a MIC value of 0.78 microg/mL towards Mycobacterium tuberculosis H37Rv and displays similar or identical MIC figures towards various drug-resistant strains of this microorganism. The enone 1 along with a partial structure 2-dimethylaminomethylcyclohexanone hydrochloride 3 affected respiration in isolated rat liver mitochondria differently which may contribute to the variation in toxicity to both normal cells and M. tuberculosis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antitubercular Agents / pharmacology*
  • Chlorocebus aethiops
  • Cyclohexanes / pharmacology
  • Drug Resistance
  • In Vitro Techniques
  • Mannich Bases / pharmacology*
  • Methylamines / pharmacology
  • Microbial Sensitivity Tests
  • Mitochondria / drug effects
  • Mitochondria / metabolism
  • Mycobacterium tuberculosis / drug effects*
  • Oxygen Consumption / drug effects
  • Rats
  • Vero Cells

Substances

  • 2-(4-(4-methoxyphenylcarbonyloxy)benzylidene)-6-dimethylaminomethyl cyclohexanone hydrochloride
  • Antitubercular Agents
  • Cyclohexanes
  • Mannich Bases
  • Methylamines