Abstract
2-[4-(4-Methoxyphenylcarbonyloxy)benzylidene]-6-dime-thylaminomethyl cyclohexanone hydrochloride 1 has a MIC value of 0.78 microg/mL towards Mycobacterium tuberculosis H37Rv and displays similar or identical MIC figures towards various drug-resistant strains of this microorganism. The enone 1 along with a partial structure 2-dimethylaminomethylcyclohexanone hydrochloride 3 affected respiration in isolated rat liver mitochondria differently which may contribute to the variation in toxicity to both normal cells and M. tuberculosis.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antitubercular Agents / pharmacology*
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Chlorocebus aethiops
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Cyclohexanes / pharmacology
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Drug Resistance
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In Vitro Techniques
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Mannich Bases / pharmacology*
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Methylamines / pharmacology
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Microbial Sensitivity Tests
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Mitochondria / drug effects
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Mitochondria / metabolism
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Mycobacterium tuberculosis / drug effects*
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Oxygen Consumption / drug effects
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Rats
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Vero Cells
Substances
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2-(4-(4-methoxyphenylcarbonyloxy)benzylidene)-6-dimethylaminomethyl cyclohexanone hydrochloride
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Antitubercular Agents
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Cyclohexanes
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Mannich Bases
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Methylamines