Dysfunction of the pulmonary homograft used in the reconstruction of the right ventricle exit tract

Arq Bras Cardiol. 2011 Jan;96(1):2-7. doi: 10.1590/s0066-782x2010005000158. Epub 2010 Dec 10.
[Article in English, Portuguese, Spanish]

Abstract

Background: The pulmonary homograft has been used as an option in the correction of congenital cardiopathy with obstruction of the right ventricle exit tract. The long term results, however, are little satisfactory.

Objective: Identify the risk factors associated to the dysfunction and the pulmonary homograft failure.

Methods: Study with children submitted to the enlargement of the exit tract of the right ventricle with pulmonary homograft. The clinical, surgical, evolutional and morphological aspects of the prosthesis variables were analyzed as risk factors.

Results: The final sample of 75 patients with median age at the surgery of 22 months, varying from 1-157 months, presented 13 patients (17.0%) who developed dysfunction of the homograft, characterized by stenosis or severe pulmonary insufficiency. The occurrence time between the homograft implant and the detection of the dysfunction was of 45 ± 20 months. When the size of the homograft was smaller than 21 mm and the Z score of the pulmonary valva is lower than zero, or higher than three, the risk factors were considered for the dysfunction occurrence.

Conclusion: The pulmonary homograft smaller than 21 mm and the inadequate pulmonary valva for the age and weight of the patient are determining factors for the prosthesis dysfunction.

MeSH terms

  • Adolescent
  • Aortic Valve / transplantation*
  • Child
  • Child, Preschool
  • Female
  • Heart Valve Prosthesis*
  • Heart Ventricles* / abnormalities
  • Heart Ventricles* / surgery
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Proportional Hazards Models
  • Prosthesis Failure / etiology*
  • Pulmonary Valve / surgery*
  • Risk Factors
  • Ventricular Outflow Obstruction / surgery*