Platinum-catalyzed cyclization reaction of alkynes: synthesis of azepino[3,4-b]indol-1-ones

Org Biomol Chem. 2011 Feb 21;9(4):1148-59. doi: 10.1039/c0ob00728e. Epub 2010 Dec 13.

Abstract

Novel azepino[3,4-b]indol-1-ones were synthesized from alkyne-substituted indole-2-carboxamides by catalytic intramolecular cyclization in the presence of PtCl(2). The scope and limitations of this straightforward protocol are reported.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkynes / chemistry*
  • Azepines / chemistry*
  • Catalysis
  • Cyclization
  • Indoles / chemical synthesis*
  • Molecular Structure
  • Platinum / chemistry*

Substances

  • Alkynes
  • Azepines
  • Indoles
  • Platinum
  • indole