Synthesis and biological activity of novel phenyltriazolinone derivatives

Qiongyou Wu; Guodong Wang; Shaowei Huang; Long Lin; Guangfu Yang

doi:10.3390/molecules15129024

Synthesis and biological activity of novel phenyltriazolinone derivatives

Molecules. 2010 Dec 9;15(12):9024-34. doi: 10.3390/molecules15129024.

Authors

Qiongyou Wu¹, Guodong Wang, Shaowei Huang, Long Lin, Guangfu Yang

Affiliation

¹ Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, Hubei, China. qywu@mail.ccnu.edu.cn

Abstract

Phenyltriazolinones are one of the most important classes of herbicides targeting the protoporphyrinogen oxidase enzyme. A series of triazolinone derivatives containing a strobilurin pharmacophore were designed and synthesized with the aim of discovering new phenyltriazolinone analogues with high activity. The herbicidal activity of the synthesized compounds was assayed and some of the test compounds displayed moderate herbicidal activity at 150 g ai/ha.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Herbicides / chemical synthesis*
Herbicides / chemistry*
Plant Proteins / antagonists & inhibitors*
Plants / enzymology*
Protoporphyrinogen Oxidase / antagonists & inhibitors*

Substances

Herbicides
Plant Proteins
Protoporphyrinogen Oxidase