Abstract
A calcium silicate and calcium phosphate (CaSiO(3)/CaHPO(4)·2H(2)O) composite coating was applied by a chemical reaction to Mg-Zn-Mn-Ca alloy to improve its biocompatiblity. The surface microstructure was observed by scanning electronic microscopy (SEM) and the surface bioactivity was assessed by a cell interaction experiment. SEM observation showed that a microporous layer was formed on the surface of Mg-Zn-Mn-Ca alloy. It was shown by XRD that the reaction layer was mainly composed of CaHPO(4)·2H(2)O and a small amount of CaSiO(3). In vitro cell experiments indicated that osteoblasts showed good adhesion, high growth rates and proliferation characteristics on the coated Mg-Zn-Mn-Ca alloy, indicating that the surface cytocompatibility of Mg-Zn-Mn-Ca alloy was significantly improved by the calcium phosphate coating.
2010 Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alloys / pharmacology*
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Animals
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Calcium Compounds / chemistry
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Calcium Compounds / pharmacology*
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Calcium Phosphates / chemistry
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Calcium Phosphates / pharmacology*
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Cell Cycle / drug effects
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Cell Proliferation / drug effects
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Cell Shape / drug effects
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Cells, Cultured
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Coated Materials, Biocompatible / chemistry
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Coated Materials, Biocompatible / pharmacology*
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Electrochemical Techniques
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Hydrogen-Ion Concentration / drug effects
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Materials Testing / methods*
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Metals / chemistry*
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Osteoblasts / cytology*
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Osteoblasts / drug effects
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Phase Transition / drug effects
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Rats
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Rats, Sprague-Dawley
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Silicates / chemistry
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Silicates / pharmacology*
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Surface Properties / drug effects
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Time Factors
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X-Ray Diffraction
Substances
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Alloys
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Calcium Compounds
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Calcium Phosphates
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Coated Materials, Biocompatible
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Metals
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Silicates
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calcium phosphate
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calcium silicate