Does DNA methylation in the promoter region of the ATXN3 gene modify age at onset in MJD (SCA3) patients?

Clin Genet. 2011 Jan;79(1):100-2. doi: 10.1111/j.1399-0004.2010.01508.x.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Age of Onset*
  • Ataxin-3
  • Child
  • DNA Methylation*
  • Gene Expression Regulation, Developmental
  • Humans
  • Machado-Joseph Disease* / diagnosis
  • Machado-Joseph Disease* / genetics
  • Machado-Joseph Disease* / physiopathology
  • Middle Aged
  • Nerve Tissue Proteins / genetics*
  • Nerve Tissue Proteins / metabolism*
  • Nuclear Proteins / genetics*
  • Nuclear Proteins / metabolism*
  • Promoter Regions, Genetic*
  • Repressor Proteins / genetics*
  • Repressor Proteins / metabolism*
  • Sequence Analysis
  • Trinucleotide Repeat Expansion
  • Young Adult

Substances

  • Nerve Tissue Proteins
  • Nuclear Proteins
  • Repressor Proteins
  • ATXN3 protein, human
  • Ataxin-3