Cucurbitane triterpenoids from Momordica charantia and their cytoprotective activity in tert-butyl hydroperoxide-induced hepatotoxicity of HepG2 cells

Chem Pharm Bull (Tokyo). 2010 Dec;58(12):1639-42. doi: 10.1248/cpb.58.1639.

Abstract

Two novel pentanorcucurbitane triterpenes, 22-hydroxy-23,24,25,26,27-pentanorcucurbit-5-en-3-one (1) and 3,7-dioxo-23,24,25,26,27-pentanorcucurbit-5-en-22-oic acid (2) together with a new trinorcucurbitane triterpene, 25,26,27-trinorcucurbit-5-ene-3,7,23-trione (3) were isolated from the methyl alcohol extract of the stems of Momordica charantia. The structures of the new compounds were elucidated by spectroscopic methods. Compounds 2 and 3 showed potent cytoprotective activity in tert-butyl hydroperoxide (t-BHP)-induced hepatotoxicity of HepG2 cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cytoprotection / drug effects
  • Glycosides / chemistry*
  • Hep G2 Cells
  • Humans
  • Hydrogen Peroxide / metabolism
  • Magnetic Resonance Spectroscopy
  • Molecular Conformation
  • Momordica charantia / chemistry*
  • Triterpenes / chemistry*
  • Triterpenes / isolation & purification
  • Triterpenes / toxicity

Substances

  • 22-hydroxy-23,24,25,26,27-pentanorcucurbit-5-en-3-one
  • 25,26,27-trinorcucurbit-5-ene-3,7,23-trione
  • 3,7-dioxo-23,24,25,26,27-pentanorcucurbit-5-en-22-oic acid
  • Glycosides
  • Triterpenes
  • cucurbitane
  • Hydrogen Peroxide