Abstract
Two novel pentanorcucurbitane triterpenes, 22-hydroxy-23,24,25,26,27-pentanorcucurbit-5-en-3-one (1) and 3,7-dioxo-23,24,25,26,27-pentanorcucurbit-5-en-22-oic acid (2) together with a new trinorcucurbitane triterpene, 25,26,27-trinorcucurbit-5-ene-3,7,23-trione (3) were isolated from the methyl alcohol extract of the stems of Momordica charantia. The structures of the new compounds were elucidated by spectroscopic methods. Compounds 2 and 3 showed potent cytoprotective activity in tert-butyl hydroperoxide (t-BHP)-induced hepatotoxicity of HepG2 cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cytoprotection / drug effects
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Glycosides / chemistry*
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Hep G2 Cells
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Humans
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Hydrogen Peroxide / metabolism
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Magnetic Resonance Spectroscopy
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Molecular Conformation
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Momordica charantia / chemistry*
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Triterpenes / chemistry*
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Triterpenes / isolation & purification
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Triterpenes / toxicity
Substances
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22-hydroxy-23,24,25,26,27-pentanorcucurbit-5-en-3-one
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25,26,27-trinorcucurbit-5-ene-3,7,23-trione
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3,7-dioxo-23,24,25,26,27-pentanorcucurbit-5-en-22-oic acid
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Glycosides
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Triterpenes
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cucurbitane
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Hydrogen Peroxide