Recent biomimetic and organocatalytic syntheses of alpha-tocopherol

Antoinette Chougnet; Kegang Liu; Wolf D Woggon

doi:10.2533/chimia.2010.303

Recent biomimetic and organocatalytic syntheses of alpha-tocopherol

Chimia (Aarau). 2010;64(5):303-8. doi: 10.2533/chimia.2010.303.

Authors

Antoinette Chougnet¹, Kegang Liu, Wolf D Woggon

Affiliation

¹ Department of Chemistry, University of Basel, St. Johanns-Ring 19, CH-4056 Basel.

PMID: 21138075
DOI: 10.2533/chimia.2010.303

Abstract

We report here on our efforts to develop new strategies for the synthesis of alpha-tocopherol, the biologically most significant member of the vitamin E family. This review comprises five new methods to generate the chiral chromane of alpha-tocopherol with overall up to 29% yield from commercially available material and up to 94% de.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Antioxidants / chemical synthesis*
Antioxidants / chemistry
Catalysis
Chromans / chemistry
Molecular Conformation
Molecular Mimicry
Proline / analogs & derivatives
Stereoisomerism
alpha-Tocopherol / chemical synthesis*
alpha-Tocopherol / chemistry

Substances

Antioxidants
Chromans
Proline
alpha-Tocopherol