Graphene-CuO nanocomposite was synthesized by a simple wet chemical approach. Using Cu(CH3COO)2 as the starting material, CuO was synthesized and loaded on the graphene sheets through the reaction with NH3H2O in alkaline system. Transmission electron microscopy, powder X-ray diffraction, X-ray photoelectron spectroscopy and Thermogravimetric analysis were employed to characterize the as-prepared sample. The detailed investigations revealed that the nanoparticles, which loaded on the graphene sheets, were pure CuO with the size of approximately 4-10 nm and possessed a monoclinic structure.