An inductively coupled plasma mass spectrometry (ICP-MS) for determination of the contents of six elements, Cd, Cr, Pb, Zn, Cu and Ni in drinking water has been developed in the present work. The operating parameters were optimized. 45Sc, 72Ge, 115In and 209Bi were chosen as the internal elements and the effect of matrix, interface and fluctuation of instrument was overcome effectively. Collision/reaction technology was used to eliminate the interference of polyatomic ion. Satisfactory linearity of working curves of six elements was obtained, giving all their correlation coefficients over 0.9997. The determination limit of the analytes were in the range of 0.70-77.0 ng x L(-1). The RSD was between 0.47% and 1.69%. GBW08607 was determined and the result was in the range of the standard. Drinking water of four areas was determined, the recoveries of the sample were 92%-108%. The method is simple, quick, accurate and stable, and can be used as a reliable method to determine trace elements in drinking water.