The research was aimed at studying molecular genetics basis of human longevity. The genotyping of polymorphisms in genes of interleukin 6 (IL-6, 7p21, -572G>C, rs1800796), 10 (IL-10, 1q31-q32, -627C>A, rs1800792), 12, (IL-12B, 5q31.1-q33.1, -1159C>A) and tumor necrosis factor-alpha (TNF-alpha, 6p21.3, -308G>A, rs1800629) from ethnically homogeneous population (Tatars from Bashkortostan Republic) has been carried out. Distributions of allele and genotypes frequencies in different age groups including old men and long-livers have been characterized. Associations have been revealed between age and -627C>A polymorphism of IL-10 gene in men, -572G>C polymorphism of IL-6 gene and -308G>A polymorphism of TNF-alpha gene in women. As a whole the data obtained by us confirm the assumption that polymorphism of cytokine genes can influence on human lifespan.