A questionnaire study was performed amongst subjects travelling to high-risk areas for traveller's diarrhoea and who had been prescribed the oral cholera vaccine Dukoral. The study was performed in 2006 at two travel medicine centres in northern Italy. One-hundred subjects participated in the study and completed the questionnaire. Compliance with the vaccine was very good (83.2%) and no serious adverse reactions were reported. 14.3% of vaccinated subjects reported diarrhoea.