G-octamer formation from N⁹ modified guanine derivatives

Nucleosides Nucleotides Nucleic Acids. 2010 Nov;29(11):801-8. doi: 10.1080/15257770.2010.528113.

Abstract

The properties of the self-assembly of two lipophilic guanine derivatives, 2',3',5'-O-tris(tert-butyldimethylsilyl)-guanosine and N⁹-(3,5-bis(tert-butyldimethylsilyloxy)-benzyl)-guanine, are described. In the presence of K+, both guanine derivatives self-associate into D₄-symmetric octamers consisting of two G-quartets stacked around a central ion.

MeSH terms

  • Circular Dichroism
  • G-Quadruplexes*
  • Guanosine / analogs & derivatives*
  • Guanosine / chemistry
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Organosilicon Compounds / chemistry*
  • Potassium / chemistry

Substances

  • 2',3',5'-O-tert-butyldimethylsilyl-N-tert-butyldimethylsilyl-8-(13)C-guanosine
  • Organosilicon Compounds
  • Guanosine
  • Potassium