Abstract
The properties of the self-assembly of two lipophilic guanine derivatives, 2',3',5'-O-tris(tert-butyldimethylsilyl)-guanosine and N⁹-(3,5-bis(tert-butyldimethylsilyloxy)-benzyl)-guanine, are described. In the presence of K+, both guanine derivatives self-associate into D₄-symmetric octamers consisting of two G-quartets stacked around a central ion.
MeSH terms
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Circular Dichroism
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G-Quadruplexes*
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Guanosine / analogs & derivatives*
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Guanosine / chemistry
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Organosilicon Compounds / chemistry*
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Potassium / chemistry
Substances
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2',3',5'-O-tert-butyldimethylsilyl-N-tert-butyldimethylsilyl-8-(13)C-guanosine
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Organosilicon Compounds
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Guanosine
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Potassium