Cytotoxic thiocarbamate derivatives of boldine

Nat Prod Commun. 2010 Oct;5(10):1587-90.

Abstract

Two new boldine derivatives: the 3-thiocarbamateboldine (3) and the 2,9-O,O-diacetyl-3-thiocarbamateboldine (4) have been synthesized and their cytotoxicity evaluated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemical synthesis*
  • Aporphines / chemical synthesis*
  • Aporphines / chemistry*
  • Aporphines / isolation & purification
  • Cell Line, Tumor
  • Drug Evaluation, Preclinical
  • Humans
  • Peumus / chemistry*
  • Thiocarbamates / chemical synthesis*
  • Thiocarbamates / chemistry*
  • Thiocarbamates / isolation & purification

Substances

  • 2,9-O,O-diacetyl-3-thiocarbamateboldine
  • 3-thiocarbamateboldine
  • Antineoplastic Agents, Phytogenic
  • Aporphines
  • Thiocarbamates
  • boldine