Abstract
Analogs of vancomycin and pseudo-vancomycin with new sugar attachments in mono- and di-saccharide form have been enzymatically synthesized by glycosylation with overexpressed glycosyltransferases, β1,4-galactosyltransferase and α2,3-sialyl transferases. All four analogs, including galactose-containing derivatives (6 and 8) and galactose- and sialic acid-containing derivatives (7 and 9) were prepared and characterized by HPLC, LC-MS, NMR and MIC test.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology
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Chromatography, Liquid
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Galactose / analogs & derivatives
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Galactose / chemistry
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Galactose / metabolism
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Galactose / pharmacology
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Galactosyltransferases / metabolism*
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Glycosylation
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Glycosyltransferases / metabolism*
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Microbial Sensitivity Tests
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N-Acetylneuraminic Acid / analogs & derivatives
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N-Acetylneuraminic Acid / chemistry
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N-Acetylneuraminic Acid / metabolism
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N-Acetylneuraminic Acid / pharmacology
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Vancomycin / analogs & derivatives*
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Vancomycin / biosynthesis*
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Vancomycin / chemistry
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Vancomycin / pharmacology
Substances
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Anti-Bacterial Agents
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Vancomycin
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Glycosyltransferases
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Galactosyltransferases
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N-Acetylneuraminic Acid
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Galactose