Abstract
Exposure to toxic and carcinogenic metals is widespread; however, their mechanisms of action remain largely unknown. One potential mechanism for metal-induced carcinogenicity and toxicity is centrosome amplification. Here we review the mechanisms for metal-induced centrosome amplification, including arsenic, chromium, mercury and nano-titanium dioxide.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Arsenic / toxicity*
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Carcinogens / toxicity
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Cell Line
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Centrosome / drug effects*
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Centrosome / metabolism*
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Chromium / toxicity*
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Environmental Exposure
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Humans
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Mercury / toxicity*
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Nanostructures / toxicity
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Titanium / chemistry
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Titanium / toxicity*
Substances
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Carcinogens
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Chromium
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titanium dioxide
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Titanium
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Mercury
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Arsenic