Excavatoids O and P, new 12-hydroxybriaranes from the octocoral Briareum excavatum

Mar Drugs. 2010 Oct 12;8(10):2639-46. doi: 10.3390/md8102639.

Abstract

Two new 12-hydroxybriarane diterpenoids, designated as excavatoids O (1) and P (2), were isolated from the octocoral Briareum excavatum. The structures of briaranes 1 and 2 were established on the basis of extensive spectral data analysis. Excavatoid P (2) is the first metabolite which possesses a 6β -chlorine atom in briarane analogues.

Keywords: Briareum excavatum; briarane; excavatoid; octocoral.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthozoa* / growth & development
  • Anthozoa* / metabolism
  • Diterpenes / chemistry*
  • Diterpenes / pharmacology*
  • Humans
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Neutrophils / drug effects
  • Pancreatic Elastase / metabolism
  • Stereoisomerism

Substances

  • Diterpenes
  • excavatoid O
  • excavatoid P
  • Pancreatic Elastase