Abstract
Biocompatible glyco-dendronized poly-l-lysine (PLL) polymers carry either three or nine mannose- or galactose-bearing dendrons that selectively bind, and thus can be used to detect, bacteria. Central to the synthesis of glyco-dendronized polymers was the development of a continuous flow [2 + 2] photocycloaddition reaction to connect the dendrons and PLL. Glycodendronized polymers cluster bacteria by binding to cell-surface carbohydrate receptors and thereby result in an easy read-out using microscopic analyses.
Publication types
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Evaluation Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Biosensing Techniques / methods*
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Dendrimers / chemistry*
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Dendrimers / metabolism
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Escherichia coli / isolation & purification*
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Escherichia coli / metabolism
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Galactose / chemistry
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Galactose / metabolism
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Mannose / chemistry*
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Mannose / metabolism
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Microscopy, Atomic Force
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Microscopy, Fluorescence
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Nanotubes / chemistry
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Nanotubes / ultrastructure
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Photochemistry
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Polylysine / chemistry*
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Sensitivity and Specificity
Substances
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Dendrimers
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Polylysine
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Mannose
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Galactose