Abstract
Schisandrin B (Sch B) and schisandrin C (Sch C), but not schisandrin A and dimethyl diphenyl bicarboxylate, protected rat skin tissue against solar irradiation-induced oxidative injury, as evidenced by a reversal of solar irradiation-induced changes in cellular reduced glutathione and α-tocopherol levels, as well as antioxidant enzyme activities and malondialdehyde production. The cytochrome P-450-mediated metabolism of Sch B or Sch C caused ROS production in rat skin microsomes. Taken together, Sch B or Sch C, by virtue of its pro-oxidant action and the subsequent eliciting of a glutathione antioxidant response, may prevent photo-aging of skin.
Copyright © 2010 Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antioxidants / metabolism
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Antioxidants / pharmacology
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Antioxidants / therapeutic use*
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Cyclooctanes / metabolism
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Cyclooctanes / pharmacology
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Cyclooctanes / therapeutic use
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Cytochrome P-450 Enzyme System / metabolism
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Glutathione / metabolism
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Lignans / metabolism
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Lignans / pharmacology
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Lignans / therapeutic use*
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Malondialdehyde / metabolism
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Oxidative Stress / drug effects*
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Phytotherapy*
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Plant Extracts / pharmacology
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Plant Extracts / therapeutic use
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Polycyclic Compounds / metabolism
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Polycyclic Compounds / pharmacology
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Polycyclic Compounds / therapeutic use*
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Radiation Injuries / drug therapy*
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Rats
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Rats, Sprague-Dawley
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Schisandra / chemistry*
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Skin / drug effects*
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Skin / metabolism
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Skin / radiation effects
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Sunlight / adverse effects
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alpha-Tocopherol / metabolism
Substances
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Antioxidants
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Cyclooctanes
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Lignans
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Plant Extracts
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Polycyclic Compounds
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schizandrin B
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Malondialdehyde
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Cytochrome P-450 Enzyme System
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Glutathione
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alpha-Tocopherol