Pegfilgrastim overdose: case report and review of the literature

Orit Kaidar-Person; Mor Moskovitz; Tomer Charas; Wasim Alsharbati; Nissim Haim

doi:10.1007/s12032-010-9751-5

Pegfilgrastim overdose: case report and review of the literature

Med Oncol. 2011 Dec:28 Suppl 1:S697-8. doi: 10.1007/s12032-010-9751-5. Epub 2010 Nov 24.

Authors

Orit Kaidar-Person¹, Mor Moskovitz, Tomer Charas, Wasim Alsharbati, Nissim Haim

Affiliation

¹ Division of Oncology, Rambam Health Care Campus, POB 9602, 31096 Haifa, Israel.

PMID: 21107754
DOI: 10.1007/s12032-010-9751-5

Abstract

Single-dose pegfilgrastim is commonly used for the prophylaxis of neutropenia in patients receiving myelotoxic chemotherapy. We report a case of a 69-year-old man who was treated with chemotherapy for small-cell lung cancer and mistakenly self-administered a 36 mg overdose of pegfilgrastim, a sixfold increase over the scheduled dose.

Publication types

Case Reports
Review

MeSH terms

Aged
Drug Overdose
Filgrastim
Granulocyte Colony-Stimulating Factor / administration & dosage
Granulocyte Colony-Stimulating Factor / adverse effects*
Humans
Male
Medication Errors / adverse effects*
Polyethylene Glycols
Recombinant Proteins / administration & dosage
Recombinant Proteins / adverse effects
Self Care / adverse effects*
Self Care / methods

Substances

Recombinant Proteins
Granulocyte Colony-Stimulating Factor
pegfilgrastim
Polyethylene Glycols
Filgrastim