The functional valency of dodecamannosylated fullerenes with Escherichia coli FimH--towards novel bacterial antiadhesives

Chem Commun (Camb). 2011 Jan 28;47(4):1321-3. doi: 10.1039/c0cc04468g. Epub 2010 Nov 22.

Abstract

Fullerene hexakis-adducts bearing 12 peripheral mannose moieties have been prepared by grafting sugar derivatives onto the fullerene core and assayed as inhibitors of FimH, a bacterial adhesin, using isothermal titration calorimetry, surface plasmon resonance and hemagglutination assays.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adhesins, Escherichia coli / chemistry*
  • Calorimetry
  • Escherichia coli / metabolism*
  • Fimbriae Proteins / chemistry*
  • Fullerenes / chemistry*
  • Hemagglutination Inhibition Tests
  • Mannose / chemistry
  • Surface Plasmon Resonance

Substances

  • Adhesins, Escherichia coli
  • Fullerenes
  • fimH protein, E coli
  • Fimbriae Proteins
  • Mannose