This paper presents results from a clinical study of stroke survivors using an adaptive, mixed-reality rehabilitation (AMRR) system for reach and grasp therapy. The AMRR therapy provides audio and visual feedback on the therapy task, based on detailed motion capture, that places the movement in an abstract, artistic context. This type of environment promotes the generalizability of movement strategies, which is shown through kinematic improvements on an untrained reaching task and higher clinical scale scores, in addition to kinematic improvements in the trained task.