Spiral wave induced numerically using electrical stimulation and comparison with experimental results

Annu Int Conf IEEE Eng Med Biol Soc. 2010:2010:2650-3. doi: 10.1109/IEMBS.2010.5626540.

Abstract

Experiments in vitro on a Microelectrode Array (MEA) platform show that electrical stimulation can provoke the generation of spiral waves in cardiac tissue. Nevertheless, the conditions leading to this artificial fibrillation state remain unclear. In order to have a better understanding of this phenomenon, a numerical simulation study has been conducted. The results obtained with a two-dimensional FitzHugh-Nagumo model proved that it is possible to create spiral waves by adding a stimulation current under certain conditions, which are made explicit.

MeSH terms

  • Action Potentials / physiology*
  • Algorithms
  • Animals
  • Animals, Newborn
  • Arrhythmias, Cardiac
  • Biomedical Engineering / methods
  • Cells, Cultured
  • Computer Simulation
  • Electric Stimulation*
  • Electrodes
  • Electrophysiology / methods*
  • Heart
  • Models, Cardiovascular
  • Models, Statistical
  • Myocardium / cytology
  • Rats