Database of genetic studies of bipolar disorder

Psychiatr Genet. 2011 Apr;21(2):57-68. doi: 10.1097/YPG.0b013e328341a346.

Abstract

This study describes the construction and preliminary analysis of a database of summary level genetic findings for bipolar disorder from the literature. The database is available for noncommercial use at http://bioprogramming.bsd.uchicago.edu/BDStudies/. This may be the first complete collection of published gene-specific linkage and association findings on bipolar disorder, including genome-wide association studies. Both the positive and negative findings have been incorporated so that the statistical and contextual significance of each finding may be compared semi-quantitatively and qualitatively across studies of mixed technologies. The database is appropriate for searching a literature populated by mainly underpowered studies, and if 'hits' are viewed as tentative knowledge for future hypothesis generation. It can serve as the basis for a mega-analysis of candidate genes. Herein, we discuss the most robust and best replicated gene findings to date in a contextual manner.

MeSH terms

  • Bipolar Disorder / genetics*
  • Databases, Genetic*
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study
  • Humans