Mutated variant of Candida antarctica lipase B in (S)-selective dynamic kinetic resolution of secondary alcohols

Karin Engström; Michaela Vallin; Per-Olof Syrén; Karl Hult; Jan-E Bäckvall

doi:10.1039/c0ob00748j

Mutated variant of Candida antarctica lipase B in (S)-selective dynamic kinetic resolution of secondary alcohols

Org Biomol Chem. 2011 Jan 7;9(1):81-2. doi: 10.1039/c0ob00748j. Epub 2010 Nov 17.

Authors

Karin Engström¹, Michaela Vallin, Per-Olof Syrén, Karl Hult, Jan-E Bäckvall

Affiliation

¹ Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE-106 91, Stockholm, Sweden.

PMID: 21082131
DOI: 10.1039/c0ob00748j

Abstract

An (S)-selective dynamic kinetic resolution of secondary alcohols, employing a mutated variant of Candida antarctica lipase B (CalB) gave products in 84-88% yield and in 90-97% ee.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alcohols / chemistry*
Alcohols / metabolism
Candida / chemistry
Candida / enzymology*
Candida / genetics
Fungal Proteins
Kinetics
Lipase / genetics
Lipase / metabolism*
Molecular Structure
Mutation*

Substances

Alcohols
Fungal Proteins
Lipase
lipase B, Candida antarctica