Abstract
Synthetic oligodeoxynucleotide is purified by capping failure sequences with an acrylated phosphoramidite followed by polymerization and product extraction. The method is suitable for large scale oligonucleotide drug purification.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Base Sequence
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Chromatography, High Pressure Liquid
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Oligodeoxyribonucleotides / chemical synthesis*
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Oligodeoxyribonucleotides / chemistry
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Oligodeoxyribonucleotides / isolation & purification
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Organophosphorus Compounds / chemistry
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Polymerization
Substances
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Oligodeoxyribonucleotides
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Organophosphorus Compounds
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phosphoramidite