Abstract
A 59-year-old Chinese male patient was admitted at diagnosis of type 1 diabetes with ketoacidosis. During the normalization of blood glucose with insulin, the patient developed acute hemolysis. The factors predisposing to hemolysis were not found, except the significantly diminished activity of glucose-6-phosphate dehydrogenase (G6PD). DNA analysis did not show any coding or intronic mutation in the G6PD gene. This is the first reported case of a Chinese patient in diabetic ketoacidosis with hemolysis induced by G6PD deficiency in the absence of mutations in the G6PD gene.
MeSH terms
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China
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Diabetes Mellitus, Type 1 / complications
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Diabetes Mellitus, Type 1 / enzymology*
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Diabetes Mellitus, Type 1 / genetics
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Diabetes Mellitus, Type 1 / pathology
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Diabetic Ketoacidosis / enzymology*
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Diabetic Ketoacidosis / etiology
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Diabetic Ketoacidosis / genetics
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Diabetic Ketoacidosis / pathology
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Glucosephosphate Dehydrogenase / genetics
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Glucosephosphate Dehydrogenase / metabolism
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Glucosephosphate Dehydrogenase Deficiency / complications
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Glucosephosphate Dehydrogenase Deficiency / genetics
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Glucosephosphate Dehydrogenase Deficiency / metabolism*
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Glucosephosphate Dehydrogenase Deficiency / pathology
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Hemolysis
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Humans
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Male
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Middle Aged
Substances
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Glucosephosphate Dehydrogenase